Dr. Putluri's lab is applying mass spectrometry technology to study metabolic profiling studies in cancer development and progression. Our lab established a robust research program in bladder cancer research. Particularly, we have characterized metabolic alterations associated with smoking in bladder cancer, health disparity and defined a role xenobiotic metabolism in bladder cancer progression. We use a variety of pre-clinical models including cancer cell lines, Organoid cultures, patient-derived xenografts (PDXs), and genetically engineered mouse models (GEMM). We are seeking highly motivated senior research Associate, who is interested in translational tumor research.

• Collects, compiles and analyzes data.
• Prepares and conducts laboratory research experiments.
• Collaborates with scientists out of the lab for multidisciplinary study.
• Develops new model and technique to support the cancer-related research in the lab.
• Operate all the mass spectrometry instrumentation needed for the projects (training will be provided as needed).
• Document experimental procedures in precise details.
• Collect and compile imaging data.
• Assist in day to day operation of running scientific research lab.
• Attend Lab Meetings.
• The project involves studying epigenetic mechanisms using in vitro, ex vivo, and in vivo models.
• Conducts independent research in the field of cancer metabolism.
• The focus of our laboratory is cancer metabolism and tumorigenesis.
• Involves a combination of metabolomics, genomics, epigenomics, shRNA KD, CRISPR-gene editing approaches, over expression and a variety of model systems including cell line, organoids, mice and PDXs.
• Seeks external funding via grants applications/submissions.
• Conducts literature searches and summarizes information in an appropriate format for a particular study.
• Should write the IACUC, IRB and IBC reports and ensure these are kept updated.
• Demonstrates competency in method development, execution, data analysis, and interpretation of metabolomics profiling and quantitative targeted assays.

• MD or Ph.D. in Basic Science, Health Science, or a related field.
• No experience required.

• Prior experiences in tissue culture and basic molecular biology techniques (e.g., PCR, DNA purification, Western blot, etc.).
• Experience with handling animal models including performing/maintaining therapeutic experiments using mouse models will be plus.
• Experience with LCMS or Cancer metabolism will be plus.

Baylor College of Medicine requires employees to be fully vaccinated -subject to approved exemptions-against vaccine-preventable diseases including, but not limited to, COVID-19 and influenza.

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

 16436

PD; SN